Category Archives: Cancers

Why Do BAP1 Mutations Cause Mesothelioma?

Mechanistic understanding of cancers continues to accelerate, with important implications for tort litigation. A recent new study by He et al. (2019) provides new insights into how and why germline BAP1 mutations are involved in the development of some cancers, such as mesothelioma, but not others. The new insights are about tissue specific actions of […]

Signature Mutations Might be the Best Alternative Cause Defense You Never Heard Of

An important feature that has emerged from this new genomic knowledge is known as “signature mutations.” In short, specific exposures cause specific patterns of mutations to occur in tumors. These mutation patterns within the cancer tissue therefore serve as a clear marker for that specific exposure (hence the term “signature mutation”).

Overview of Rare Disease Registries and U.S. Cancer Registries

Our post yesterday explained work in progress to create a national mesothelioma patient registry. That development should be viewed in the broader context of rare disease registries in general. On that topic, an open access article is Lacaze P,  et al, Rare disease registries: a call to action. Intern Med J. 2017 Sep;47(9):1075-1079. The article […]