Category Archives: Genomics General

Webinar – Legal and Ethical Challenges in Mesothelioma Cases Involving Young People

For first of its kind new data related to the growing number of lawsuits involving young people with mesothelioma, please join next week’s Perrin webinar: Legal and Ethical Challenges in Young Mesothelioma Cases. One key fact is the cases often involve people who have medical histories that include a range of benign tumors, cysts, cancers and/or […]

Genomic Evidence Essential to Asbestos and Talc Cases: Dr. Len van Zyl Presents at Perrin National Conference

On September 9, Dr. Len van Zyl of ToxicoGenomica presented at Perrin Conferences’ National Asbestos Litigation Conference at the Fairmont San Francisco Hotel. The conference was greatly attended, and attendees were provided with key information on the trends that are currently driving asbestos litigation and the impact these trends may have on future cases. Dr. […]

Perrin conference

The Application of Genomics in Asbestos and Talc Cases: Dr. Len van Zyl will be Speaking at the Perrin National Asbestos Litigation Conference

On September 9-11, Dr. Len van Zyl of ToxicoGenomica will be speaking at Perrin Conferences’ National Asbestos Litigation Conference at the  Fairmont San Francisco Hotel, San Francisco, CA. This marks the tenth anniversary of the three-day conference which provides attendees with a deeper understanding of the trends currently driving asbestos litigation and the impact these […]

DNA

Signature Mutations Might be the Best Alternative Cause Defense You Never Heard Of

An important feature that has emerged from this new genomic knowledge is known as “signature mutations.” In short, specific exposures cause specific patterns of mutations to occur in tumors. These mutation patterns within the cancer tissue therefore serve as a clear marker for that specific exposure (hence the term “signature mutation”).

Looking Forward to the Incredible Scale and Pace of Genomics in the Near Future

We work with genomics every day, but sometimes it’s difficult to convey  the scale and pace of the gathering and analysis of genomic data. That said, graphics can help, as shown below. The graphic clearly shows the decline in cost and the associated consumer adoption of genetic techniques in the near future. The publisher of […]

Hand is inserting sequence of DNA. Genetic engineering, GMO and Gene manipulation concept.

New Paper Explores Heritable Genetic Factors Related To Mesothelioma

A new paper by Kharazmi and colleagues present important data regarding the heritable nature of mesothelioma using epidemiological techniques to analyze the population-based Swedish Cancer Registry. The results, reported in the European Journal of Cancer, are important because the findings confirm that both genes and exposures are relevant, and on their face, appear helpful to […]

Scientist looking at DNA

The Meso Gene [Download ACI Presentations]

The ongoing revolution in genomic science is having an impact on many facets of modern life, including toxic tort litigation. This point was apparent at the recently held American Conference Institute’s 23rd National Forum on Asbestos Claims & Litigation (May 21-23, 2018) in Chicago, where we presented in a session titled “The Meso Gene.” In […]

Litigators Guide to a Genomic Defense

The Litigator’s Guide to Using Genomics in a Toxic Tort Case

Genomics is a proven and reliable quantitative tool that has dramatically improved cancer treatment, established the practice of personalized medicine, and brought binary clarity to paternity and criminal cases. Genomics is now transforming how civil toxic tort cases are adjudicated. We have hit a tipping point where, instead of merely relying on population-based epidemiological studies, […]

Predisposition vs Susceptibility

What is the Difference Between Predisposition and Susceptibility in a Genetic Defense?

As the application of genomic sciences becomes common in toxic tort litigation, savvy litigators are occasionally concerned that genomic information may backfire on the defense. Specifically, defense lawyers worry that plaintiff’s counsel may allege that an exposure to a minute amount of a toxicant caused an injury through an individual’s unique genetic pathway. This can […]