Category Archives: Genomics General

Genomic Evidence Essential to Asbestos and Talc Cases: Dr. Len van Zyl Presents at Perrin National Conference

On September 9, Dr. Len van Zyl of ToxicoGenomica presented at Perrin Conferences’ National Asbestos Litigation Conference at the Fairmont San Francisco Hotel. The conference was greatly attended, and attendees were provided with key information on the trends that are currently driving asbestos litigation and the impact these trends may have on future cases. Dr. […]

DNA

Signature Mutations Might be the Best Alternative Cause Defense You Never Heard Of

An important feature that has emerged from this new genomic knowledge is known as “signature mutations.” In short, specific exposures cause specific patterns of mutations to occur in tumors. These mutation patterns within the cancer tissue therefore serve as a clear marker for that specific exposure (hence the term “signature mutation”).

Looking Forward to the Incredible Scale and Pace of Genomics in the Near Future

We work with genomics every day, but sometimes it’s difficult to convey  the scale and pace of the gathering and analysis of genomic data. That said, graphics can help, as shown below. The graphic clearly shows the decline in cost and the associated consumer adoption of genetic techniques in the near future. The publisher of […]

Scientist looking at DNA

The Meso Gene [Download ACI Presentations]

The ongoing revolution in genomic science is having an impact on many facets of modern life, including toxic tort litigation. This point was apparent at the recently held American Conference Institute’s 23rd National Forum on Asbestos Claims & Litigation (May 21-23, 2018) in Chicago, where we presented in a session titled “The Meso Gene.” In […]

Litigators Guide to a Genomic Defense

The Litigator’s Guide to Using Genomics in a Toxic Tort Case

Genomics is a proven and reliable quantitative tool that has dramatically improved cancer treatment, established the practice of personalized medicine, and brought binary clarity to paternity and criminal cases. Genomics is now transforming how civil toxic tort cases are adjudicated. We have hit a tipping point where, instead of merely relying on population-based epidemiological studies, […]

Predisposition vs Susceptibility

What is the Difference Between Predisposition and Susceptibility in a Genetic Defense?

As the application of genomic sciences becomes common in toxic tort litigation, savvy litigators are occasionally concerned that genomic information may backfire on the defense. Specifically, defense lawyers worry that plaintiff’s counsel may allege that an exposure to a minute amount of a toxicant caused an injury through an individual’s unique genetic pathway. This can […]

Scientist looking at DNA

Some Important Factors to Consider When Using Genomic Science in Toxic Tort Litigation

As the application of genomic science becomes more common in toxic tort litigation, savvy litigators are thinking about how statements about genetic findings may fit into legal categories or terms of art. In our view, non-scientists need to keep in mind that words used as terms of art for genetic findings are not necessarily equivalent […]

Taq polymerase PCR enzyme

Protein-Based Adverse Drug Reactions (ADRs): Using Proteomics to Assess Drug Safety

Each year, adverse drug events cost millions of dollars in hospital admissions, injuries to patients, and malpractice. And companies spend billions of dollars on litigation involving allegations that their drugs caused adverse drug reactions (ADRs). What if there was a better way to determine individualized drug adverse events? Welcome to the Age of Proteomics The […]

Gene Editing

Toxic Tort Lawyers: It’s Time to Join the Genetic Revolution

Due to scientific advances in molecular biology, questions about a person’s DNA are more frequently becoming prominent in civil law, including “toxic tort” cases. To date, evidence about inherited DNA mutations has been instrumental in cases involving medication(s), vaccines, benzene, asbestos, and/or tobacco. This post provides an overview of some articles and events illustrating some […]

Genetic testing concept, DNA icon, medical doctor, isolated on white

5 Toxic Tort Cases Where Genomic Science Was Successfully Applied

To avoid needless ethical and/or legal disputes and to avoid wasting time and money, it’s important to think about genomic issues early on in a case. It’s also useful to look across sets of cases to get a clearer understanding of how genomics can provide an effective strategy. In general, it’s desirable and cost-effective to […]